Supports joint strength, liver detoxification, mood and brain function.

SAMe 400 (S-Adenosyl Methionine) by Jarrow Formulas provides a full 400 mg SAMe (net yield) from 800 mg of SAMetosylate disulfate. Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid).

SAMeis a chiral molecule and consists of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.

Joint Strength: SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.

Liver: SAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase glutathione reductase and glutathione-S-transferase), which are substances important for liver function, including phase II detoxification.

Brain Metabolism: SAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).

Ingredients: Full Potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate. Other Ingredients: Cellulose, mannitol, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, sodium starch glycolate and an enteric coating (modified cellulose, magnesium silicate, triethyl citrate and riboflavin).

This product does not contain wheat, gluten, soybeans, dairy, egg, fish/shellfish or peanuts/tree nuts.

Suggested Use:
Take 1 tablet 1 or 2 times per day on an empty stomach or as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to using this product if you use prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAMe. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset. If you experience discomfort, discontinue use.

Keep out of reach of children.